Translational and Clinical Pharmacology  2017;25(3):117-124

doi:10.12793/tcp.2017.25.3.117

Intracerebroventricular drug administration.

Arthur J. ATKINSON 1

Affiliations

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Keywords

Intracerebroventricular drug administration; Cerebrospinal fluid physiology; Pharmacokinetics; Meningitis; CNS cancer

Country

Republic of Korea

Language

English

Abstract

Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. This route has been shown to be particularly useful in administering to the central nervous system (CNS) drugs that do not cross the blood-brain barrier readily. As such, the ICV route is a valuable option for providing therapeutic CNS drug concentrations to treat patients with CNS infectious and neoplastic diseases. This route of drug administration also has the advantage of minimizing systemic toxicity.