Objective To understand the epidemiological features of syphilis in Qingpu District for developing control strategies. Methods The data of syphilis cases(2009-2018)were collected and analyzed. Results The reported syphilis incidence decreased from 27.17/10⁵ in 2009 to 24.69/10⁵ in 2018. The ratio of secondary syphilis declined from 64.98% in 2009 to 57.14% in 2018, while that of latent syphilis increased from 23.74% in 2009 to 32.89% in 2018. The incidence of syphilis was higher in males than in females, and the average male/female ratio increased from 1.01:1 in 2009 to 1.51:1 in 2018. The incidence of syphilis was the highest in the age group of 20-59 years, but the constituent ratio increased in the aged group(≥ 60 year). The cases were mainly in the local household register, but the composition ratio showed a downward trend from 81.71% in 2009 to 59.14% in 2018. The main source of cases was STD outpatients. It decreased from 89.11% in 2009 to 46.51% in 2018, and the proportion of inpatients and other outpatients increased from 8.56% in 2009 to 50.49% in 2018. Conclusion The incidence of syphilis shows a decreasing trend. The incidence of reported secondary syphilis has decreased in general but increased rapidly in older patients. More measures are urgently in need to control epidemic syphilis effectively.