Korean Journal of Clinical Microbiology  2007;10(1):1-5

RNAi: A Recent Revolutionary Tool for Understanding of Basic Biology.

Dong Kil JUNG 1 ; Young Suk CHO ; Won Kil LEE

Affiliations

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Keywords

RNAi; Gene-silencing; Gene function; Therapeutic potential

Country

Republic of Korea

Language

Korean

Abstract

RNA interference (RNAi) is a gene-silencing technology by which small double-stranded RNAs are used to target the degradation of RNA with complementary sequence. RNAi is found in a wide variety of organisms (Caenorhabditis elegans, insects, plants, microorganisms and animals). With RNAi, we have harnessed the gene function to be explored, revolutionized our ability to perform large-scale genetic screens, and even therapeutic potential.