Journal of Bone Metabolism  2014;21(3):227-232

doi:10.11005/jbm.2014.21.3.227

A Case of Cavernous Sinus Thrombophlebitis and Meningitis as a Complication in Osteopetrosis.

Hyun Chul CHUNG 1 ; So Hyun PARK ; Eun Sook KIM ; Young Il KIM ; Sun Ho LEE ; Il Seong NAM-GOONG

Affiliations

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Keywords

Cavernous sinus thrombosis; Meningitis; Osteopetrosis

Country

Republic of Korea

Language

English

Abstract

Osteopetrosis is a rare genetic bone disease characterized by increased bone density but prone to breakage due to defective osteoclastic function. Among two primary types of autosomal dominant osteopetrosis (ADO), osteopetrosis type II is characterized by sclerosis of bones, predominantly involving the spine, the pelvis, and the skull base. Fragility of bones and dental abscess are leading complications. This report presents a case of osteopetrosis in a 52-years-old female, which was complicated by the development of cavernous sinus thrombophlebitis and meningitis. She was suffered from multiple fractures since one year ago. Laboratory data revealed elevated serum levels of tartrate resistant acid phosphatase (TRAP) without carbonic anhydrase II DNA mutation. A thoracolumbar spine X-ray showed, typical findings of ADO type II (ADO II; Albers-Schonberg disease), prominent vertebral endplates so called the 'rugger jersey spine'. Her older sister also showed same typical spine appearance. We report a case of ADO II with cavernous sinus thrombophlebitis and meningitis that was successfully treated with long-term antibiotics with right sphenoidotomy.