PURPOSE: The aim of this study was to identify factors affecting student adjustment to college among students in health colleges (Nursing, Clinical Pathology, Radiology, Dental Hygienics, Medicine). METHODS: The participants in this study were 261 students in Daejeon city. Data were collected from October 5 to October 14, 2014. A structured questionnaire was used for data collection and data was analyzed using the SPSS/WIN program. RESULTS: Career attitude maturity, calling and work as meaning positively correlated with student adjustment to college. The significant predictors of student adjustment to college were career attitude maturity, calling, always working part-time, major in medicine and average grade for the last semester. CONCLUSION: These findings suggest that adjustment to college for students in health colleges is linked to career attitude maturity, and calling. College organization should develop a curriculum fostering a calling which will promote student adjustment to college and graduate health care professionals with desirable attitudes.