Chinese Herbal Medicines 2020;12(4):359-366

doi:10.1016/j.chmed.2020.05.007

Brusatol: A potential anti-tumor quassinoid from Brucea javanica

Xiao-qi YU 1

Affiliations

+expand

Keywords

antitumor; Brucea javanica (L.) Merr.; brusatol; triterpene lactone

Country

China

Language

Chinese

Abstract

Brusatol, a triterpene lactone compound mainly from Brucea javanica, sensitizes a broad spectrum of cancer cells. It is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. In this review, we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in vivo. This review also covers pharmacokinetics studies, modification of dosages forms of brusatol. Increasing evidences have validated the value of brusatol as a chemotherapeutic agent in cancers, which may contribute to drug development and clinical application.