Chinese Journal of Natural Medicines (English Ed.) 2020;18(10):729-737

doi:10.1016/S1875-5364(20)60013-9

Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors.

Zi-Pei ZHANG 1 ; Wan-Ying XUE 1 ; Jian-Xing HU 1 ; De-Cai XIONG 1 ; Yan-Fen WU 2 ; Xin-Shan YE 3

Affiliations

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Keywords

Enzyme assay; Molecular docking; Pyrano[2, 3-d]trizaole; α-Glucosidase inhibitor

Country

China

Language

English

Abstract

A series of novel pyrano[2, 3-d]trizaole compounds were synthesized and their α-glucosidase inhibitory activities were evaluated by in vitro enzyme assay. The experimental data demonstrated that compound 10f showed up to 10-fold higher inhibition (IC74.0 ± 1.3 μmol·L) than acarbose. The molecular docking revealed that compound 10f could bind to α-glucosidase via the hydrophobic, π-π stacking, and hydrogen bonding interactions. The results may benefit further structural modifications to find new and potent α-glucosidase inhibitors.