The Korean Journal of Hepatology  2004;10(4):313-318

A Case of Nodular Regenerative Hyperplasia of Liver that mimicked Primary Biliary Cirrhosis.

Sung Gon SHIM 1 ; Joo Hyun SOHN ; Jae Woong LEE ; Young Woo CHUNG ; Chang Hee PAIK ; Jong Pyo KIM ; Yong Chul JEON ; Dong Soo HAN ; Joon Soo HAHM ; Dong Hoo LEE ; Choon Suhk KEE ; Young Ha OH

Affiliations

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Keywords

Nodular regenerative hyperplasia; Primary biliary cirrhosis; Liver needle biopsy

Country

Republic of Korea

Language

Korean

Abstract

Nodular regenerative hyperplasia (NRH) of the liver is a rare disease that is characterized by multiple regenerative nodules in the hepatic parenchyma without fibrosis. The exact pathogenesis of NRH has not been established, but it's been suggested that obliteration of portal veins may initiate the nodular transformation. It is also known that this disease is associated with autoimmune disease, myeloproliferative disease, lymphoproliferative disease, primary biliary cirrhosis, and some chemotherapy agents. The patients with NRH are usually asymptomatic, yet if they have symptoms, the most common clinical manifestations are those of portal hypertension, including splenomegaly and esophageal varices with or without bleeding. We report a case of nodular regenerative hyperplasia that presented with clinical manifestations similar to those of primary biliary cirrhosis.