Journal of Pharmaceutical Practice 2020;38(4):301-306

doi:10.12206/j.issn.1006-0111.201910082

Preparation and formulation optimization of wound dressings with nitrocellu-lose as membrane material

Lingna ZHANG 1 ; Tianyu WANG 1 ; Wanfeng HONG 1 ; Chun TAO 1 ; Hongtao SONG 1

Affiliations

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Keywords

wound dressing; nitrocellulose; , formulation optimization

Country

China

Language

Chinese

Abstract

Objective To prepare a wound dressing using nitrocellulose as a membrane and optimize its formulation. Methods Partial analysis was performed on commercial available products. The wound dressings were prepared by using nitrocellulose as a film-forming material, benzyl alcohol as a bacteriostatic agent, castor oil as a plasticizer, isopropyl palmitate as a skin emollient, camphor as a fragrance, and isopropyl alcohol, ethyl acetate and butyl acetate as volatile solvent. The tensile strength, breakpoint elongation percentage, breathability and waterproof performance were tested and evaluated. Results The film-forming performance of the prepared liquid wound dressing was good. The final use amount of nitrocellulose was determined to be 6%. The use amount of plasticizer castor oil was determined to be 4%. Conclusion The prepared liquid wound dressing has good film-forming property, good mechanical property, good waterproof and certain breathability.