Organ Transplantation 2020;11(3):321-

doi:10.3969/j.issn.1674-7445.2020.03.001

The function of regulatory immunological cell in xenotransplantation immunity

Bingyi SHI 1 ; Wen CHEN ; Zhijia LIU

Affiliations

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Keywords

Regulatory immunological cell; Xenotransplantation; Rejection; Transplantation immunity; Regulatory T cell (Treg); Regulatory dendritic cell (DCreg); Follicular regulatory T cell (Tfr); Regulatory B cell (Breg)

Country

China

Language

Chinese

Abstract

Xenotransplantation is the most promising method to resolve the organ shortage problem in the future. In recent years, the advances in gene editing and immunological technique have driven the rapid development of xenotransplantation. However, there are still many insurmountable obstacles in the clinical application of xenotransplantation, among which the rejection is the most important cause of the xenotransplantation failure. Regulatory immunological cells are a group of immunological cells with the negative regulation function in the body, which can inhibit allotransplantation rejection and prolong the survival time of the graft. This paper summarized the research progress of regulatory immunological cells in the xenotransplantation application in recent years, providing reference for the prevention and treatment of xenotransplantation rejection.