Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2020;34(2):128-130

doi:10.13201/j.issn.1001-1781.2020.02.007

Analysis of the effect of endoscopic surgery combined with conventional surgery in Neuroblastoma

Wei GAO 1 ; Yinfeng WANG 1 ; Yalin WANG 1 ; Tao GUO 1 ; Xianguang LI 1 ; Fei YIN 1 ; Chunchen PAN 1 ; Jingwu SUN 1

Affiliations

+expand

Keywords

esthesioneuroblastoma; radiation therapy; treatment effect

Country

China

Language

Chinese

Abstract

Objective:The aim of this study is to evaluate the efficacy of endoscopic surgery and conventional surgery combined with radiotherapy in the treatment of Neuroblastoma.

Method:Forty-three patients with olfactory neuroblastoma undergoing surgery combined with radiotherapy were retrospectively analyzed. The patients were divided into endoscopic surgery and conventional surgery. All patients received postoperative radiotherapy at a dose of 60-70 Gy, the 5-year survival rate and local recurrence time of the two groups were compared, and the therapeutic effects of endoscopic surgery and traditional surgery were compared.

Result:Through survival analysis, the 5-year overall survival rates of the traditional surgery group and the endoscopic surgery group were 50% and 58% （P=0.560）, the local recurrence rates were 44% and 48% （P=0.288）, and the mean recurrence time was 5.6 months and 12.5 months （P=0.032）.

Conclusion:There was no difference between endoscopic surgery and conventional surgery combined with radiotherapy in the treatment of Neuroblastoma, and the time of local recurrence was significantly prolonged. In early Neuroblastoma, endoscopic sinus surgery may be superior to open surgery in terms of efficacy and patient survival.