Journal of the Korean Geriatrics Society  2011;15(4):234-239

doi:10.4235/jkgs.2011.15.4.234

A Case of Demyelinating Peripheral Neuropathy Associated with Hashimoto's Thyroiditis.

Jung Hwan PARK 1 ; Sang Mo HONG ; Chang Bum LEE ; Yong Soo PARK ; Dong Sun KIM ; Woong Hwan CHOI ; You Hern AHN

Affiliations

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Keywords

Hashimoto's thyroiditis; Polyradiculoneuropathy; Steroids

Country

Republic of Korea

Language

Korean

Abstract

Peripheral neuropathy is somewhat common in hypothyroidism. But, demyelinating peripheral neuropathy in Hashimoto's thyroiditis is extremely rare. The pathophysiology of demyelinating peripheral neuropathy associated with Hashimoto's thyroiditis is unclear and complex and various mechanisms including the cell mediated and antibody mediated responses may be operative. We report a 68-year-old woman who presented with paresthesia and gait disturbance. She was diagnosed with hypothyroidism 7 years prior and has been on thyroid hormone. Serum antithyroglobulin antibody was significantly elevated. Nerve conduction studies revealed sensory-motor demyelinating polyneuropathy with prolonged distal latencies and reduced conduction velocities. She was under the suspicion of the lymphoma of thyroid. Surgery was performed which turned up to be Hashimoto's thyroiditis. With the impression of rare demyelinating peripheral neuropathy associated with Hashimoto's thyroiditis after other causes were excluded, she was treated with steroid which ameliorated rapidly her neurological symptoms.