Journal of Pharmaceutical Practice 2020;38(2):124-128

doi:10.3969/j.issn.1006-0111.201908132

Determination of the content of Gd3+ in gadoteric acid meglumine salt injection by ICP-MS method

Qirong WANG 1 ; Jieyi CHEN 1 ; Miao SUN 1 ; Yuping CHEN 1 ; Feng YANG 1

Affiliations

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Keywords

ICP-MS; gadoteric acid meglumine salt injection; Gd3+; content determination

Country

China

Language

Chinese

Abstract

Objective To establish a method for determining the content of Gd3+ in gadoteric acid meglumine salt injection. Methods ICP-MS was used. The separation column was a metal chelate column (1-ml Chelating Sepharose column), column temperature was normal temperature. Flow rate was 1 ml/min. Injection volume was 500 μl. Atoms were measured by ICP-MS with a molecular weight of 157 (The molecular weight of Gd was 157). The carrier gas was argon. Results The linear range of Gd3+ mass concentration was 0-500 ng/ml (r=1.000); The precision, stability and repeatability of the sample recovery test were all in accordance with the requirements. Conclusion The method was simple in operation, accurate in results and good in repeatability, which could be used to determine the content of Gd3+ in gadoteric acid meglumine salt injection.