Journal of Pharmaceutical Practice 2020;38(2):105-109

doi:10.3969/j.issn.1006-0111.201912096

Advances in research on the impact of the plateau environmental on the drug metabolism

Zizhao GAO 1 ; Rong WANG 1 ; Anpeng ZHAO 2

Affiliations

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Keywords

therapeutic drug monitoring; therapeutic window; drug metabolism; plateau hypoxia; rational use

Country

China

Language

Chinese

Abstract

Plateau environment will affect the metabolism of drugs in the body, which will cause changes in pharmacokinetic parameters, expression and function of drug metabolizing enzymes and transporters. With the rapid development of the pharmaceutical industry, therapeutic drug monitoring (TDM) has been widely paid attention to as a basis for personalized drugs. What impact does the plateau environment on monitoring drugs? In this literature review, we will summarize the types of commonly used therapeutic monitoring drugs, therapeutic windows, and blood samples, analyze the effects of plateau hypoxic environment on the metabolism of commonly used monitoring drugs, provide a reference for the clinical treatment and monitoring drugs of plateau, better ensure the rational use of drugs in the plateau population, and also provide a reference for the later research group to conduct the monitoring of plateau therapeutic drugs and the selection of research drugs.