Organ Transplantation 2020;11(2):194-

doi:10.3969/j.issn.1674-7445.2020.02.003

Research progress on biomarkers of rejection risk in organ transplantation

Bingyi SHI 1 ; Wen CHEN ; Zhijia LIU

Affiliations

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Keywords

Organ transplantation; Transplantation immunity; Rejection; Transplantation pathology; Immune cell; Non-human leukocyte antigen antibody; Exosomes; Cell-free DNA(cfDNA); Combination gene prediction

Country

China

Language

Chinese

Abstract

Rejection is the main cause of transplantation failure. Currently, the specificity and sensitivity of clinical parameters are relatively poor, which cannot accurately prompt the exact cause of rejection. It is of great clinical significance to explore novel biomarkers for monitoring the rejection. In this article, the latest research progress on the biomarkers of rejection risk in organ transplantation were summarized from the perspectives of transplantation pathology, immune cells and regulatory immune cells, non-human leukocyte antigen antibodies, exosomes, cell-free DNA and combination gene prediction, aiming to provide reference for early warning and treatment of rejection in organ transplantation.