Annals of Clinical Microbiology  2015;18(3):94-97

doi:10.5145/ACM.2015.18.3.94

Successful Treatment of Fungemia Caused by Cyberlindnera fabianii with Anidulafungin: A Case Report.

Jeong In LEE 1 ; Shinae YU ; Jong Sin PARK ; Eun Jeong JOO ; Jong Hee SHIN ; Min Jung KWON

Affiliations

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Keywords

Anidulafungin; Cyberlindnera fabianii

Country

Republic of Korea

Language

English

Abstract

Cyberlindnera fabianii (previously known as Hansenula fabianii, Pichia fabianii, and Lindnera fabianii) is a yeast species that forms a biofilm, allowing it to resist azole drugs. In this study, we report a case of fungemia with C. fabianii that was successfully treated with anidulafungin. In this case, the organism was initially misidentified as Candida utilis (with a high probability of 93%, suggesting good identification) using the VITEK 2 yeast identification card (YST ID; bio-Merieux, USA). The species responsible for the patient's fungemia was correctly identified after sequencing the internally transcribed spacer region and the D1/D2 domain of the large subunit (26S) rDNA gene. The CLSI M27-A3 broth microdilution method was used to determine the in vitro antifungal activity of anidulafungin and fluconazole against C. fabianii. The MICs of anidulafungin and fluconazole were found to be 0.03 microg/mL and 2 microg/mL, respectively. The patient recovered after 14 days of anidulafungin treatment.