Chinese Journal of Natural Medicines (English Ed.) 2017;15(12):905-911

doi:10.1016/S1875-5364(18)30006-2

Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects.

Yuan WEI 1 ; Dan-Juan SUI 2 ; Hai-Miao XU 2 ; Zhen OUYANG 2 ; Na WU 2 ; Du-Jun WANG 2 ; Xiao-Yan ZHANG 2 ; Da-Wei QIAN 3

Affiliations

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Keywords

Anti-inflammation effects; Atractylodes lancea; CYP3A; Licorice; Triptolide

Country

China

Language

English

MeSH

Abstract

The present study was designed to explore the influence of water extracts of Atractylodes lancea rhizomes on the toxicity and anti-inflammatory effects of triptolide (TP). A water extract was prepared from A. lancea rhizomes and co-administered with TP in C57BL/6 mice. The toxicity was assayed by determining serum biochemical parameters and visceral indexes and by liver histopathological analysis. The hepatic CYP3A expression levels were detected using Western blotting and RT-PCR methods. The data showed that the water extract of A. lancea rhizomes reduced triptolide-induced toxicity, probably by inducing the hepatic expression of CYP3A. The anti-inflammatory effects of TP were evaluated in mice using a xylene-induced ear edema test. By comparing ear edema inhibition rates, we found that the water extract could also increase the anti-inflammatory effects of TP. In conclusion, our results suggested that the water extract of A. lancea rhizomes, used in combination with TP, has a potential in reducing TP-induced toxicity and enhancing its anti-inflammatory effects.