Chinese Journal of Natural Medicines (English Ed.) 2017;15(12):950-954

doi:10.1016/S1875-5364(18)30012-8

Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis.

Shi-Fei LI 1 ; Shun-Lin LI 2

Affiliations

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Keywords

Cassia occidentalis; Cycloartane triterpenoid; Cycloccidentalic acid C; Cycloccidentaliside VI

Country

China

Language

English

MeSH

Abstract

In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C (1) and its glucoside, cycloccidentaliside VI (2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC value of 1.44 μmol·L and TI (Therapeutic Index) value of 15.59.