Korean Journal of Gastrointestinal Motility  2001;7(1):56-64

A Multicenter Clinical Trial of Cisapride Tartrate in Diabetic Patients with Dysmotility Like Dyspeptic Symptoms.

Sun Myung KIM 1 ; Kyo Young CHOO ; Myung Gyu CHOI ; Jin Il KIM ; Choon Sang BHANG ; Sok Won HAN ; Byung Wook KIM ; Hwang CHOI ; Sung Soo KIM ; Dong Soo LEE ; Kyu Yong CHOI ; Moo Il KANG ; In Sik CHUNG

Affiliations

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Keywords

Cisapride tartrate; Dyspepsia; Diabetes

Country

Republic of Korea

Language

Korean

Abstract

BACKGROUND/AIMS: We evaluated the effects of cisapride tartrate on gastrointestinal symptoms and gastric emptying times in diabetic patients with dysmotility like dyspeptic symptoms. METHODS: Cisapride was administered before each meal in 61 patients for 4 weeks. The intensity of gastrointestinal symptoms before and after cisapride administration was scored from 0 to 4, in the order of increasing severity of symptoms. In addition, a gastric emptying test was performed. RESULTS: A significant reduction in the total intensity score of symptoms was observed during the first two weeks, from 8.5+/-2.1 to 4.0+/-3.0 (p < 0.05), and a further reduction was noted during the next two weeks, to 2.8+/-2.8 (p < 0.05). Good to excellent improvement was obtained in 70.4% of the patients, but the improvement in symptoms was not related to age, duration of diabetes, glucose, Hb A1c, neuropathy, or retinopathy. Treatment with cisapride induced a significant regression of symptoms and a significant improvement of delayed gastric emptying from 104.0+/-31.7 minutes to 79.5+/-17.1 (p < 0.05). However, there was a lack of association between the changes in gastric emptying times and improvements in symptoms(r(2)=0.00186). Only 3 patients complained of loose stool, nausea, or dizziness. CONCLUSIONS: Cisapride was effective in improving dysmotility like dyspeptic symptoms in diabetic patients without serious side effects.