Journal of Leukemia & Lymphoma 2019;28(11):676-677

doi:10.3760/cma.j.issn.1009-9921.2019.11.008

Development and application of anti-human platelet and anti-thrombotic monoclonal antibodies

Miao JIANG 1 ; Shundong JI ; Kesheng DAI ; Changgeng RUAN

Affiliations

+expand

Keywords

Blood platelets; Antibodies; Thrombosis

Country

China

Language

Chinese

Abstract

Since its inception, anti-platelet antibodies have been an important tool for studying the interaction of platelets with blood components and blood vessels. At the same time, anti-platelet antibodies also play an important role in the detection and diagnosis of hemorrhagic and thrombotic diseases, and become a kind of powerful anti-thrombotic drugs. With the further understanding of the role of platelets in physiological hemostasis and pathological thrombosis, anti-platelet and anti-thrombotic antibodies also seek a balance between better anti-thrombotic effects and less bleeding side effects.