Chinese Journal of Nuclear Medicine and Molecular Imaging 2019;39(11):688-693

doi:10.3760/cma.j.issn.2095-2848.2019.11.013

Research progress of CD13-targeted molecular probe in tumor neovascularization imaging and therapy

Minghao WU 1 ; Yanyan ZHANG ; Lin CAO ; Xuening ZHANG ; Zhaoxiang YE

Affiliations

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Keywords

Neoplasms; Neovascularization, pathologic; Angiogenesis inhibitors; Antigens, CD13; Trends

Country

China

Language

Chinese

Abstract

Tumor neovascularization plays an important role in the occurrence, development and metastasis of cancer. Non-invasive quantification and detection of tumor neovascularization is crucial for early diagnosis and prognosis assessment of cancer. Targeted molecular imaging has arisen in vascular targeting imaging and precise treatment based on the molecular characteristics of neovascularization. Aminopeptidase N (APN, or CD13) is a multifunctional membrane-bound exopeptidase that is overexpressed in neovascular endothelial cells and some tumor cells but rarely expressed in normal blood vessels, which makes it a potential target for tumor neovascularization imaging and anti-angiogenic therapy. This review summarizes the application progress and the future development trend of target molecular imaging and precise treatment based on CD13.