Journal of Leukemia & Lymphoma 2019;28(12):705-708

doi:10.3760/cma.j.issn.1009-9921.2019.12.001

Application progress of transcriptome sequencing in hematological malignancies

Hongxing LIU 1 ; Xue CHEN 2 ; Fang WANG 2 ; Xiaoli MA 2 ; Lili YUAN 2 ; Panxiang CAO 2 ; Daijing NIE 2

Affiliations

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Keywords

High-throughput nucleotide sequencing; Transcriptome; Gene sequencing; Fusion genes; Gene mutations; Hematological malignancies

Country

China

Language

Chinese

Abstract

Transcriptome sequencing (RNA-seq) has unique advantages in analyzing gene fusion, splicing mutations, and gene expression profiles. Single-cell RNA-seq provides powerful tools to reveal cellular heterogeneity in normal and tumor tissues. With the widespread application of high-throughput gene sequencing technology and the rapid reduction in cost, RNA-seq is increasingly used in hematological malignancies research. This article introduces the related research progress in conjunction with reports at the 61st American Society of Hematology Annual Meeting.