International Eye Science 2020;20(3):404-409

doi:10.3980/j.issn.1672-5123.2020.3.02

Research progress on cell signal transduction pathway mediating age-related cataract

Zhong-Ying Wang 1

Affiliations

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Keywords

age-related cataract; apoptosis; signal transduction

Country

China

Language

Chinese

Abstract

Age-related cataract is a blinding eye disease that affects vision due to opacity of intraocular lens, ranking first in the world. Under oxidative stress, the activation of apoptosis related signal transduction pathways in lens epithelial cells is the main mechanism mediating age-related cataract. There are many related signaling pathways for apoptosis, and it is a complex network system. The purpose of this literature review is to summarize different apoptotic cell signal transduction pathways that mediate age-related cataract, laying the foundation for further researching.