Keimyung Medical Journal  2015;34(2):127-132

Pulmonary Mucormycosis Treated Successfully with Posaconazole as Salvage Therapy.

Jiwon CHOI 1 ; Yeun Seoung CHOI ; Myoung Kyu LEE ; Sang Ha KIM ; Suk Joong YONG ; Kye Chul SHIN ; Seok Jeong LEE ; Ye Ryung JUNG ; Won Yeon LEE

Affiliations

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Keywords

Mucormycosis; Posaconazole; Salvage therapy

Country

Republic of Korea

Language

English

Abstract

Mucormycosis (formerly known as zygomycosis) is a life-threatening opportunistic mycosis that infects a broad range of hosts with qualitative or quantitative defects in innate immunity. The overall mortality rate of pulmonary mucormycosis is above 70%. The prognosis and outcome of pulmonary mucormycosis have not improved significantly over the last decade, mainly because of difficulty in early diagnosis and the limited activity of current antifungal agents against members of the order Mucorales. We report a case of pulmonary mucormycosis treated successfully with posaconazole as salvage therapy. We suggest that posaconazole may be considered as an alternative therapeutic approach in patients with invasive pulmonary mucormycosis who are unable to tolerate surgical treatment.