Chinese Journal of Clinical Oncology 2019;46(14):755-759

doi:10.3969/j.issn.1000-8179.2019.14.892

Homing barriers and solutions for CAR-T cells in the treatment of solid tumors

Songlin YANG 1 ; Lin LI ; Deren DUAN ; Zongliu HOU ; Jing TAN

Affiliations

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Keywords

chimeric antigen receptor T cells (CAR-T); homing; solid tumor

Country

China

Language

Chinese

Abstract

Chimeric antigen receptor T (CAR-T) cell therapy is an emerging immunotherapy that has allowed for major breakthroughs in the treatment of hematological neoplasms. However, little progress has been made in the treatment of solid tumors, primarily due to the difficulty in homing to tumor tissues by CAR-T cells during treatment. The complex tumor microenvironment and the barrier function of tumor tissues prevent CAR-T cells from contacting tumor cells, thereby preventing them from exerting their antitumor ac-tivity. This review article summarizes not only the progress made in the study of homing disorders of CAR-T cells in the treatment of solid tumors but also the current methods to overcome these disorders.