Chinese Journal of Endocrine Surgery 2019;13(5):383-386

doi:10.3760/cma.j.issn.1674-6090.2019.05.007

Analysis of the performance of contrast-enhanced ultrasound for evaluating response to neoadjuvant chemotherapy in breast cancer

Yijie CHEN 1 ; Lina TANG ; Jian LIU ; Zhongshi DU ; Yaoqin WANG ; Zhaoming ZHONG ; Zhijian HUANG ; Qiuyan HUANG ; Weiwei HUANG

Affiliations

+expand

Keywords

Contrast-enhanced ultrasound; Breast cancer; Neoadjuvant chemotherapy; Response evaluation; Ultrasonography

Country

China

Language

Chinese

Abstract

Objective To analyze the performance of contrast-enhanced uhrasound(CEUS) in the evaluation of response to neoadjuvant chemotherapy (NAC) for breast cancer in different periods.Methods A prospective study consisting of 46 patients with invasive ductal carcinoma who received NAC and surgery subsequently was conducted.One patient underwent CEUS before NAC,after the second cycle of NAC and before surgery.CEUS outcomes were compared with histopathologic response by Kappa test using the Miller-Payne Grading(MPG) system.The changes of CEUS quantitative parameters in different periods of NAC were compared.Results 31 patients showed a good response by histopathology while 29 patients by CEUS,which showed good consistence.Kappa value was 0.713.The peak intensity (PI) of the lesions decreased significantly after the second cycle of NAC compared with that before NAC (P＜0.05).The peak intensity (PI),wash-in slope (WIS),and area under curve(AUC) of the lesions decreased significantly before surgery compared with those before NAC (P＜0.05).Conclusion CEUS shows good consistence with histopathologic outcomes.The peak intensity (PI) is a sensitive indicator of early changes after NAC.