To investigate the autonomic dysfunction in patients with Parkinson’s disease ( PD) combined with orthostatic hypotension (OH). Methods Seventy-six PD patients were selected and divided into PD-OH group (n=40) and non-OH group (n=36) after the measurement of blood pressure in the supine to standing position. The scales for outcomes in PD-autonomic test (SCOPA-AUT) was used to evaluate the patients in the two groups. Results There were significant differences in age, duration and Hoehn-Yahr stage between the two groups (all P<0.05). The total value of SCOPA-AUT in the PD-OH group was significantly higher than that in the non-OH group ( P< 0.05 ). The scores of digestive system, urinary system, cardiovascular system, sympathetic/parasympathetic system and sexual function of SCOPA-AUT in the PD-OH group were all significantly higher than those in the non-OH group (all P<0.05). Conclusion The autonomic dysfunction of PD patients with OH is more serious than that of PD patients without OH, and clinical diagnosis and management of PD patients with OH should be strengthened.