Clinical Pediatric Hematology-Oncology  2011;18(1):75-79

Tumor Lysis Syndrome in a Child with Osteosarcoma

Jung Hee SHIN 1 ; Yoon Young YI ; So Ick JANG ; Joon Sup SONG

Affiliations

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Keywords

Tumor lysis syndrome; Osteosarcoma; Children

Country

Republic of Korea

Language

Korean

Abstract

Tumor lysis syndrome (TLS) is a metabolic derangement that may be seen after the initial treatment of cancer and usually occurs in patients with bulky, rapidly proliferating, or treatment-responsive tumors such as acute leukemia or Burkitt lymphoma. However, it is rare in the treatment of the solid tumor, especially osteosarcoma. An 11-year-old girl was admitted with a 3-months history of severe right leg pain. She was diagnosed as osteosarcoma and was treated with cisplatin and adriamycin. Three days after treatment, the values of potassium, phosphorus, uric acid were 6.4 mEq/L, 5.6 mg/dL and 8.9 mg/dL, respectively. At the same time, the value of calcium was 6.2 mg/dL. Although she was treated with proper conservative treatment including dialysis, she had significant complications such as renal failure, heart failure, hypoxic brain damage. We report a case of TLS in a girl with huge osteosarcoma.