Chonnam Medical Journal  2011;47(1):48-50

doi:10.4068/cmj.2011.47.1.48

A Case of a False-Positive Anti-Myeloperoxidase Antibody ELISA in a Patient with Hypothyroidism

Mi Kyung JIN 1 ; Kwan Yong SEO ; Jin Young KANG ; Ji Young CHOI ; Se Hee YOON ; Yong Lim KIM ; Dong Il WON ; Sun Hee PARK

Affiliations

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Keywords

Hypothyroidism; Anti-thyroid peroxidase antibodg; Anti-myeloperoxi dase antibody

Country

Republic of Korea

Language

English

Abstract

We present a case of a false-positive anti-myeloperoxidase (MPO) antibody result on an ELISA in a patient with anti-thyroid microsomal antibody (TMA)-positive hypothyroidism. A 41-year-old woman presented with dyspnea on exertion. The initial evaluation revealed pericardial effusion associated with hypothyroidism. In addition, microscopic hematuria with normal renal function and positive cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) on immunofluorescent assay were found. In further evaluation, elevated anti-TMA and MPO antibodies by ELISA. While no definite signs of vasculitis were present, the clinical state improved with thyroid hormone replacement and diuretics. Anti-MPO antibody was still positive in the follow-up tests, and microscopic hematuria persisted. On the basis of previous reports that thyroid peroxidase and MPO molecules contain cross-reactive epitopes that are exposed in denaturated molecules, we suggest that in a patient with anti-TMA-positive hypothyroidism, anti-MPO antibody might also be positive on ELISA without clinical signs of vasculitis.