BACKGROUND: The purpose of this study is to investigate the influence of nursing student's communication ability, nursing professional intuition and self-esteem on clinical practice satisfaction.METHODS: Descriptive cross sectional study design was used. Data were collected from 223 nursing students using self administered surveys at a university located in a D metropolitan city in Chungcheong area. Data were managed using SPSS 20.0.RESULTS: As a result of regression analysis on clinical practice satisfaction and variables, regression analysis of clinical practice satisfaction and variables revealed that regression model was significant (F=31.80, p < .001). The adjusted coefficient of determination(adj. R2) was .358 and the explanatory power was 35.8%. The most important factors affecting the satisfaction of clinical practice were nursing professional intuition (β .371, p < .001), department satisfaction (β=.251, p < .001), communication ability (β=.166, p=.004), and grade (β=.133, p=.016).CONCLUSION: Nursing students should improve their communication ability, nursing professional intuition and department satisfaction in order to increase the satisfaction of clinical practice.