Journal of the Korean Society of Biological Therapies in Psychiatry 2019;25(1):28-35

The Association of Plasma Inflammatory Cytokines with Dementia and Mild Cognitive Impairment

Kyung Hoon SON 1 ; Su Jeong SEONG ; Won Joon LEE ; Jae Yeon HWANG ; Jae Hyun HAN ; Yeong Ju JEON ; Chang Hwan HAN

Affiliations

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Keywords

Dementia; Mild cognitive impairment; Aging; Cytokine; Tumor necrosis factor-alpha; Insulin-like growth factor-I; Interleukin-6

Country

Republic of Korea

Language

Korean

Abstract

OBJECTIVES: The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment.METHODS: We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulin-like growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIA-AA) working group.RESULTS: When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant.CONCLUSION: The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.