Journal of Digestive Cancer Report 2019;7(1):18-21

A Case of 47-Years-Old Female with Obstructive Jaundice and Weight Loss

Pil Gyu PARK 1 ; Huapyong KANG ; Moon Jae CHUNG ; Jeong Youp PARK ; Seungmin BANG ; Seung Woo PARK ; Si Young SONG ; Hee Seung LEE

Affiliations

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Keywords

Pancreatic cancer; Chronic pancreatitis; Idiopathic; Hereditary; SPINK1

Country

Republic of Korea

Language

English

Abstract

Serine protease inhibitor Kazal-type 1 (SPINK1) is a gene expressed from pancreatic acinar cell which its mutation is known to be associated with chronic pancreatitis (CP) and pancreatic cancer. We report a case of a 47-years-old female with nausea and weight loss with yellow discoloration of skin. Initial imaging and endoscopic study led us to an impression of chronic pancreatitis with pancreatic cancer with common bile-duct dilation. Biopsy result was confirmed with pancreatic adenocarcinoma and additional imaging revealed lymph node and bone metastasis. Our genetic analysis revealed 194+2T>C mutation of SPINK1. Biliary obstruction was successfully decompressed by stent insertion and underwent chemotherapy and radiotherapy. Although there is accumulating evidence of association between SPINK1 mutation and CP, the relationship between SPINK1 mutation and pancreatic cancer in CP patient is an emerging concept. Genetic analysis should be considered in patients with young age especially when diagnosed with both CP and pancreatic cancer.