Natural Product Sciences  2015;21(4):273-277

doi:10.20307/nps.2015.21.4.273

Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp..

Seong Hwan KIM 1 ; Yoonho SHIN ; Sang Kook LEE ; Jongheon SHIN ; Dong Chan OH

Affiliations

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Keywords

Marine actinomycete; Saltern; LC/MS analysis; Salternamide E; Cytotoxicity

Country

Republic of Korea

Language

English

Abstract

Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain. The planar structure of salternamide E (1) was elucidated by a combinational analysis of spectroscopic data including NMR, MS, UV, and IR. The absolute configuration of salternamide E (1) was determined by circular dichroism spectroscopic analysis. Salternamide E displayed weak cytotoxicity against various human carcinoma cell lines.