Natural Product Sciences  2015;21(4):289-292

doi:10.20307/nps.2015.21.4.289

Two New Scalaranes from a Korean Marine Sponge Spongia sp..

Inho YANG 1 ; Sang Jip NAM ; Heonjoong KANG

Affiliations

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Keywords

Scalarane; Sesterpenoid; Spongia sp.; Korean sponge; Marine natural product

Country

Republic of Korea

Language

English

Abstract

Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of 1H-1H coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.