Natural Product Sciences  2015;21(4):293-296

doi:10.20307/nps.2015.21.4.293

Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges.

Roshan R KULKARNI 1 ; A Reum JO ; Young Ho KIM ; MinKyun NA

Affiliations

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Keywords

L-isoascorbic acid; soluble epoxide hydrolase; Verongida sponges

Country

Republic of Korea

Language

English

Abstract

A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an IC50 value 51.5 +/- 1.0 microM.