Korean Journal of Endocrine Surgery  2005;5(2):109-113

doi:10.16956/kjes.2005.5.2.109

Cribriform-morular Variant Papillary Carcinoma associated with Familial Adenomatous Polyposis.

Jandee LEE 1 ; Sihoon LEE ; Chi Young LIM ; Kee Hyun NAM ; Hang Seok CHANG ; Woung Youn CHUNG ; Cheong Soo PARK

Affiliations

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Keywords

Cribriform-morular variant; Papillary thyroid carcinoma; Familial adenomatous polyposis

Country

Republic of Korea

Language

Korean

Abstract

Cribriform-morular variant (CMV) is a rare histologic subtype of papillary thyroid carcinoma (PTC). Patients with familial adenomatous polyposis (FAP) could be associated with several comorbid diseases including thyroid cancer. Most thyroid cancers in them are PTCs, but infrequently CMV types can occur. The FAP concomitant CMV-PTCs are found predominantly in young women and reveals lower recurrence rate. Moreover, this variant shows circumscribed morphology and rarely metastasizes to node. Because the incidence of thyroid carcinoma is higher than that in general population, comprehensive evaluation of thyroid gland should be performed for the patients with FAP. Because thyroid cancer could be first manifestation of FAP, colonic screening should be considered in CMV-PTC patient. We report two cases of CMV-PTCs concurrent with FAP.