Clinical Pediatric Hematology-Oncology  2019;26(2):115-118

doi:10.15264/cpho.2019.26.2.115

Two Cases of Cytomegalovirus Infection Developed in Pediatric Acute Lymphoblastic Leukemia Patients

Nayoung JUNG 1 ; Donghyun KIM ; Hee Seung CHIN ; Soon Ki KIM

Affiliations

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Keywords

Cytomegalovirus; Acute lymphoblastic leukemia

Country

Republic of Korea

Language

English

Abstract

A 14 year-old boy with acute lymphoblastic leukemia (ALL) on maintenance chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis. Treatment with intavitreal ganciclovir injection (2 mg/0.1 mL) followed by oral ganciclovir resulted in successful resolution of CMV retinitis. Another 13 year-old boy with ALL on maintenance chemotherapy presented with prolonged fever with no response to antibiotics administration. CMV and real-time PCR revealed positive result and a titer of 2,618,700 copies/mL, respectively. Ganciclovir was used for more than the approved duration of treatment, but viral titer frequently recurred with elevated liver enzymes and fever. In these 2 cases of CMV infection, a high index of suspicion and prompt management is important in children receiving ALL chemotherapy.