Dementia and Neurocognitive Disorders  2015;14(2):87-93

doi:10.12779/dnd.2015.14.2.87

Longitudinal Clinical Changes of Non-Fluent/Agrammatic Primary Progressive Aphasia as Tau Spectrum Disorder: A Case Report.

Jin Soo KIM 1 ; Jae Won JANG ; Seong Heon KIM ; Min Jeong WANG ; Young Ho PARK ; Sangyun KIM

Affiliations

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Keywords

taupathy; non-fluent/agrammatic primary progressive aphasia; corticobasal degeneration; progressive supranuclear palsy

Country

Republic of Korea

Language

English

Abstract

BACKGROUND: Tauopathies are a group of diseases caused by the accumulation of hyperphosphorylated tau protein in the central nervous system. Previous studies have revealed that there is considerable overlap in clinical, pathological, and genetic features among different taupathies. CASE REPORT: We report a patient with non-fluent/agrammatic primary progressive aphasia at the initial assessment. Over time, other symptoms belonging to corticobasal degeneration and progressive supranuclear palsy appeared in this patient. CONCLUSIONS: Clinical overlapping features in these disorders may represent different phenotypes of a single disease process.