Journal of Korean Society of Osteoporosis  2013;11(3):114-118

Efficacy of Once-Yearly Intravenous Zoledronic Acid for Osteopenia

Chang Ho SUNG 1 ; Wan Sik SEO ; Ye Soo PARK

Affiliations

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Keywords

Zoledronic acid; Osteopenia; Efficacy; FRAX

Country

Republic of Korea

Language

Korean

Abstract

OBJECTIVES: To assess the clinical efficacy of once-yearly treatment with Zoledronic acid in patients with osteopenia. MATERIALS AND METHODS: From June 2009 to November 2011, patients diagnosed with osteopenia were applied to fracture risk assessment tool (FRAX). Among them, 40 patients who showed high possibility of osteoporotic fracture were selected and treated with intravenous zoledronic acid once-yearly. At the baseline and after one year of injection of zoledronate, we measured the changes in the bone mineral density (BMD) and bone turnover markers In addition, we analyzed the side effects and thereby assessed the drug safety.