Journal of Korean Society of Osteoporosis  2011;9(1):132-138

The Study of Bisphosphonate and Postmenopausal Hormone Treatment in Low Bone Mineral Density

Soo Ah KIM 1 ; Ari KIM ; Yong il JI ; Heung Yeol KIM ; Jong Soon CHOI ; Won Jun CHOI ; Min Hyung JUNG ; Ji Young LEE ; Hyuk JUNG

Affiliations

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Keywords

Bisphosphonate; Bone mineral density; Hormone therapy; Menopause

Country

Republic of Korea

Language

Korean

Abstract

OBJECTIVES: To evaluate the effect of postmenopausal hormone therapy alone or in combination with bisphosphonate on bone mineral density (BMD) in postmenopausal women. METHODS: One hundred three women diagnosed with low BMD in postmenopausal women were included in this study. All patients were classified into two groups; oarl hormone therpy alone (Group I) or with alendronate (Group II), given for 12 months. Dual energy X-ray absorptiometry was used to measure BMD before and after 12 months of treatment. RESULTS: In all groups, significant increase in bone density measurements were seen at 12 months of treatment. The BMD of lumbar spine more increased significantly in Group II than Group I. CONCLUSIONS: Postmenopausal hormone therapy is effective in osteopenic and osteoporotic women. However, the combined treatment with hormone therapy and bisphophonate is more effective in postmenopausal women with low BMD.