Modern Hospital 2019;19(2):240-244

doi:10.3969/j.issn.1671-332X.2019.02.024

Prediction of B cell Epitopes and HLA I Restricted CTL Epitopes Derived from Tumor Antigen SCCAg

Xue HANG 1 ; La HU ; Zicheng ZENG ; Hai LIN ; Gao YI ; Zhaoyu LIU

Affiliations

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Keywords

SCCAg; B Cell Epitopes; CTL Epitopes

Country

China

Language

Chinese

Abstract

Ojbective To predicte the HLAⅠrestricted CTL epitopes and B cell antigen epitopes derived from tumor antigen SCCAg. Methods The linear B cell epitopes and conformational B cell epitopes of tumor antigen SCCAg were predicted by Ellipro program. In addition, the HLAⅠrestricted CTL epitopes of SCCAg were predicted by NetCTL, Prot-Param and so on. Results B cell epitopes analysis revealed that SCCAg had 10 potential linear B cell epitopes and 5 conformational B cell epitopes; Combined with peptide HLAⅠbinding, proteasomal C - terminal cleavage and TAP transport efficiency, the NetCTL predicts that multiple HLAⅠrestricted CTL epitopes were present in the tumor antigen SCCAg. Conclusion The B cell epitopes and HLAⅠrestricted CTL epitopes can be predicted by multiple methods, which may lay the foundation for the further research on immunotherapy for targeting SCCAg.