Asia Pacific Allergy 2011;1(1):12-15

doi:10.5415/apallergy.2011.1.1.12

Immunoglobulin E in health and disease

M AMARASEKERA 1

Affiliations

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Keywords

Immunoglobulin E; Allergy

Country

Republic of Korea

Language

English

Abstract

The discovery of immunoglobulin E (IgE) was a breakthrough in the field of Allergy and Immunology. Our understanding of mechanisms of allergic reactions and the role of IgE in these disorders has paralleled to the discovery of treatment modalities for patients with allergy. Apart from allergic diseases, IgE is involved in pathogenesis of other disorders. Much controversy exists about the control of total IgE (tIgE) levels and allergen-specific IgE (sIgE) profiles in allergic individuals. This review aims at giving a comprehensive overview of IgE molecule and discussing the issues related to its importance in clinical setting.