Korean Journal of Pediatric Hematology-Oncology  2004;11(2):265-270

A Case of Ganciclovir-resistant CMV Antigenemia by UL97 Phosphotransferase Mutant Strain after Cord Blood Transplantation.

Young Shil PARK 1 ; Yun Suk JEON ; Bin CHO ; Nak Gyun CHUNG ; Dong Gun LEE ; Su Mi CHOI ; Wan Shik SHIN ; Hack Ki KIM

Affiliations

+expand

Keywords

Cytomegalovirus; Resistance; Antivirals; UL97

Country

Republic of Korea

Language

Korean

Abstract

Despite the availability of effective antiviral drugs, human cytomegalovirus (CMV) infection is still a serious life-threatening complication in recipients of allogeneic hematopoietic stem cell transplantation. Ganciclovir (GCV) preemptive therapy is currently the usual treatment for CMV disease and antigenemia. However, prolonged GCV therapy results in the emergence of drug-resistant virus. Most GCV-resistant clinical CMV isolates contain a mutation in the UL97 phosphotransferase gene. We report a case that GCV-resistant CMV antigenemia by UL97 phosphotransferase mutant strain at codon 460 and 605 which was improved by reduction of immunosuppressants for posttransplant lymphoproliferative disease after unrelated cord blood transplantation.