Objective: To explore the therapeutic effect of Golden bifid combined with smecta for the patients with hepatogenous diarrhea (HD). Methods: 66 patients with HD were randomly divided into treatment group (n=33) and control group (n=33).On the basis of protecting the liver and the complex treatment, the treatment group was given Golden bifid (2.0g,three times a day) combined with smecta (3.0g,three times a day), and the control group was given levofloxacin (0.2g, twice a stools. the total efficiency (remarkable effect and effective) of two groups was calculated. Results: The total effective rate of treatment group was 90.9%, while that of the control group was 48.5%. There were statistically significant differences between the two groups (x2=14.19,P＜0.01). Conclusion: The clinical therapeutic effect of Golden bifid combined with smecta for the patients with hepatogenous diarrhea is remarkable,which is worth spreading in the clinical application.