Immune Network  2015;15(5):232-240

doi:10.4110/in.2015.15.5.232

A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages.

Kyung Jong WON 1 ; Sung Won PARK ; Seunghoon LEE ; Il Keun KONG ; Jung Il CHAE ; Bokyung KIM ; Eun Jong LEE ; Dong Ku KIM

Affiliations

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Keywords

TLT-6; ITIM motif; Anti-proliferation; Macrophages; TREM family

Country

Republic of Korea

Language

English

Abstract

The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages.