Chinese Journal of Experimental Ophthalmology 2018;36(12):973-976

doi:10.3760/cma.j.issn.2095.0160.2018.12.016

Advance in biomarkers of neuromyelitis optica

Jun CHEN 1

Affiliations

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Keywords

Neuromyelitis optica; Aquaporin.4; Myelin.oligodendrocyte glycoprotein; Aquaporin-1; Glial fibrillary acidic protein

Country

China

Language

Chinese

Abstract

Neuromyelitis optica ( NMO ) is an autoimmune, demyelinating disease of the central nervous system manifesting with optic neuritis and longitudinally extensive transverse myelitis. Aquaporin.4 ( AQP4 ) .IgG is currently regarded as a specific biomarker of NMO. Nevertheless,AQP4.IgG seronegativity in 10％-25％ of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis. In this article,we reviewed current knowledge about biomarkers of NMO from AQP4, myelin.oligodendrocyte glycoprotein, AQP1 and glial fibrillary acidic protein,providing a new insight in the diagnosis of NMO.