The application of antiglaucoma drugs is the main treatment for glaucoma,but there are differences in the response of patients to antiglaucoma drugs. Different races have different reactivities to prostaglandins;the same patient may has different reactivity to different prostaglandins;with the prolonged use of prostaglandins,the status of some patients have changed from being unresponsive to being reactive. The reasons for individual difference of drug response are complex. Drug receptor and metabolism gene polymorphisms are deemed as the cause of individual difference. Studying the relationship between drug responses and gene differences can realize individual therapy. This review summarized the response to antiglaucoma drugs and influence factors leading to individual difference of drug response,which may provide help for clinical individualized and precise treatment.