Objective:To explore influencing factors of recent period incidence of major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).Meth-ods:Clin data of 459 patients with acute ST elevation myocardial infarction (STEMI),who received PCI in our hos-pital from Jan 2013 to Mar 2017,were retrospectively analyzed.According to recent period incidence of MACE af-ter PCI or not,patients were divided into MACE group (n＝96) and non-MACE group (n＝363).Influencing fac-tors of recent pertiod MACE were analyzed in these patients.Results:Incidence rate of MACE was 20.92% (96/459) among the 459 patients.Compared with non-MACE group,there were significant rise in percentages of men,hypertension,hyperlipidemia,diabetes mellitus (DM),smoking,radial artery puncture and postoperative poor ST regression,aged,NYHA class,onset-to-reperfusion time,levels of cTnI,NT-proBNP,TG,LDL-C,Hcy and hsCRP,and number of coronary diseased vessels,and significant reductions in LVEF,HDL-C level and percentage of preoperative intensive statin therapy in MACE group (gender P＜0.05,else P＜0.01).Multifactor Logistic re-gression analysis indicated that age ≥68 years,DM,LDL-C≥2.83mmol/L,NT-proBNP≥3874pg/ml,hsCRP≥23.91mg/L and postoperative poor ST regression were independent risk factors for recent period MACE in STEMI patients after PCI (OR＝1.683～6.890,P＜0.01 all),and preoperative intensive statin therapy was its independent protective factor (OR＝0.543,P＝0.001).Conclusion:The incidence of recent period MACE in AMI patients after PCI is affected by many factors.Clinicians should intervene and treat patients according their risk factors in order to reduce incidence rate of MACE after PCI and improve prognosis.