Toxicological Research  2012;28(4):249-253

Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema.

Mi Young AHN 1 ; Jea Woong HAN ; Hyung Joo YOON ; Jae Sam HWANG ; Yun Eun YOUNG

Affiliations

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Keywords

Edema; Bumblebee alcohol extract

Country

Republic of Korea

Language

English

Abstract

In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.