Journal of Shenyang Medical College 2016;18(3):129-131

doi:10.16753/j.cnki.1008-2344.2016.03.001

p21WAF1/CIP and Regulation of Breast Cancer Cell Cycle

Weiqiang ZHOU 1

Affiliations

+expand

Keywords

breast cancer; p21WAF1/CIP; cell cycle

Country

China

Language

Chinese

Abstract

Abnormal proliferation is a key point for the occurrence and development of breast cancer. p21WAF1/CIP is essential to maintain a normal growth and development of the organisms, and its dysfunction can lead to organism overgrowth. The function of p21WAF1/CIP occurs mainly in post?transcriptional and transcriptional level. Especially, the transcription regulation of p21WAF1/CIP is very important to cell cycle progression of breast cancer via epigenetic change in histone deacetylation.